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Purpose: Studies have demonstrated a moderate correlative link between longitudinal right ventricular (RV) strain and RV systolic pressure (RVSP), using two-dimensional strain methodology. We sought to establish whether this relationship would hold true for longitudinal (LS), radial (RS) and circumferential (CS) strain vectors when tracked utilising three-dimensional speckle tracking (3DST) software.Methods: N=28 patients with pulmonary hypertension (PHT) and N=8 healthy volunteers (20-85 years, RVSP 23-154mmHg) with satisfactory imaging for 3DST and measurable tricuspid regurgitation were assessed. RV end-diastolic pressures (RVEDP) were obtained in a subset of N=22 patients with PHT and N=5 healthy volunteers (RVEDP 7-41mmHg). In addition to standard 2D and Doppler studies, a 3D full volume capture of the RV was acquired and analysed for RS, LS and CS.Results: RS (r= −0.522, p= 0.001) and LS (r= 0.657, p< 0.001), but not CS (r= 0.064, p= 0.711) decreased with increasing RVSP. For increasing RVEDP, LS was the only strain vector which demonstrated a significant decrease (r= 0.600, p= 0.001). RS demonstrated a weak tendency for reduced strain with increasing RVEDP (r= −0.375, p= 0.054), whilst CS did not reveal a relationship (r= 0.052, p= 0.796).Conclusion: There were moderate correlative associations between RVSP and both RS and LS, and a moderate correlation between LS and RVEDP.