P642Improvement of right ventricular function during specific drugs administration in patients with pulmonary arterial hypertension.


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Abstract

Introduction: Dedicated drugs improve functional status and hemodynamic in patients with pulmonary hypertension. Drugs effect is today not reported on right ventricular function by echocardiography. This work aims to evaluate right ventricular function before and after pre and post administration of these drugs.Methods: 20 symptomatic patients receiving the definition of pulmonary arterial hypertension (PAH) were treated by phosphodiesterase type 5 inhibitors (30%), endothelin receptor antagonists (20%) or both (50%). Echocardiographic analysis was performed before and after 4-6 months of treatment for right cavities area by planimetry, tricuspid free wall S velocity by tissue Doppler imaging, right ventricular longitudinal systolic 2D strain, peak tricuspid regurgitation velocity as well as conventional left ventricular function.Results: Mean age was 53±19 y. There were 8 men. At baseline, patients had elevated invasive mean pulmonary artery pressure (38±12 mm Hg). All were at least in NYHA functional class 3 and had reduced 6-min walking test (324±98 m). Echocardiographic findings after 4-6 of treatment are listed in table 1. Overall, the administration of dedicated drugs for PAH induced right ventricular cavities area reduction following pulmonary pressure decline, increased longitudinal right ventricular free wall displacement and deformation and positively enhanced left ventricular diastolic function.Conclusion: In addition to functional class and hemodynamic improvement, this work reports for the first time non-invasive right ventricular function enhancement by echocardiography in patients receiving specific drugs for pulmonary arterial hypertension.

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