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Behaviour of peak systolic intra ventricular presure gradient (SIVPG), which depends on inertial and convective forces, is comparablewith that of dp/dt. Global longitudinal strain (GLS) is now considered as a surrogateof LV systolicfunction (EF). The aim of this study was to evaluate therelationship betwwen SIVPG and the GLS and the effect of preload and afterloadparameters on this two variables.Methods: One hundred consecutive patients were enrolled in this study unreceptivelyof the clinical status. Mean age was 55.8 ± 18.1. On top of regular echo parameters evaluatingpreload, afterload and global LVfunctiin, the following parametes were acquired. Arterial elastance (Ae),single beat end systolic elastance (Ees), Global longitudinal strain, and SIVPG(calculated from M mode color Doppler according to the Euler equation).Results: Impact of preload and afterload parameters on GLS and SIVPG isshown on table 1. GLS correlate significantly with SIVPG (y = -14,22 + -0,54 x,r=-0.49; p<0.001). Sub group of patient with SIVPG< 8 mmHg have lowerGLS values compared to patient with SIVPG > 8 MMhG (-17.3 ±3.3, vs –19.8±3.0;p=0.0003)Conclusion: GLS is affected by pre and after load conditions and is significantlycorrelated to the systolic IVPG. In opposition this study confirms that SIVPGis relatively independent of loading conditions.