P673Adipokines and endothelium dysfunction in patients with acute myocardial infarction

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Background: Adipokines not only regulate glucose metabolism but also modulate the immune reactions and affect inflammatory processes thus may influence the pathogenesis coronary artery disease (CAD).Aim: to assess the relationship between serum adipokines levels and degree of endothelium dysfunction measured by flow mediated dilation /FMD/ in patients with acute myocardial infarction /AMI/.Methods: One hundred patients with AMI treated by primary PCI with stent implantation were enrolled into the study. Thirty patients with stable CAD constituted the control group. Blood samples were obtained at 3rd day after PCI and the serum of adiponectin, resistin, apelin, visfatin levels by ELISA method were measured.Results: Mean serum resistin, visfatin levels were significantly higher /p<0,05/ and adiponectin and apelin serum levels were significantly lower /p<0,05/ in AMI patients as compared to stable CAD subjects. There were no differences in the FMD values between the groups. In AMI patients FMD values positively correlated with serum adiponectin levels (r=0,221; p<0,05) and negatively with serum resistin (r=-0,534, p<0,05) and visfatin (r=-0,439, p<0,05) levels. In multiple regression analysis serum adiponectin, resistin, visfatin and apelin levels were independent factors influencing FMD values. Inversely relationships were observed regarding to CRP levels: resistin, visfatin negatively (r=0,526, p<0,05; r=0,352, p<0,05 respectively) and adiponectin positively correlated with CRP (r=-0,608; p<0,05). There were not any significant relationships between adipokines levels and glucose metabolism or body fat mass disturbances in AMI group.Conclusions: In patients with AMI unfavorable adipokines profile impairs endothelial function. Adipokines activation in myocardial infarction is not related to glucose metabolism and fat distribution but seems to be associated with inflammatory response.

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