P707Detection of mild diastolic dysfunction in patients with arterial hypertension by ea component of reflected high intensity motion signals

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Purpose: to date the problem of echocardiographic detection of mild diastolic dysfunction (DD) is not solved yet. In this study we aimed to analyze if early diastolic ea component of reflected high intensity motion signals (RIMS) can be used for detection of mild diastolic disturbances in patients with 1 grade of arterial hypertension (AH).Methods: 79 patients with AH grade 1 (mean age 54.5 ± 11.9 years, male 32) and 102 healthy subjects (mean age 39.9 ± 15.5 years, male 62) underwent dopplerechocardiographic exam. RIMS were registered by pulsed wave Doppler from apical 4-chamber view, when the sample volume was positioned between the tips of mitral leaflets (figure 1). Using the defined diagnosis of AH grade 1 as a referent method the cutoff value of ea for separation of healthy subjects and patients was determined.Results: mean velocity value of RIMS ea component in healthy subjects appeared to be 24.0±3.7 cm/s and in patients with AH 17.9±2.9 cm/s; p<0,0001. The cutoff value of ea ≤ 20 cm/s separated patients from healthy subjects with sensitivity 82.3% and specificity 84.3%.Conclusion: analysis of RIMS ea component can effectively detect mild DD in patients with AH grade 1.

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