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Background: Strain imaging allows detection of early cardiac impairment before reduction of contractile function, especially in anthracycline-induced cardiomyopathy.Methods: 98 pts treated with adjuvant anthracycline therapy for breast cancer were evaluated by echocardiography every 3 months since the beginning of treatment. A speckle tracking study of longitudinal end-systolic strain was performed from apical views. Values of end-systolic strain at baseline and every 3 months were compared in order to assess the occurrence and degree of cardiotoxicity.Results: The mean segmental values of end-systolic strain at each echocardiographic examination are reported in Table 1. The cumulative effect of anthracycline was evident especially in the posterior and lateral walls.Conclusions: Significant changes in myocardial strain values reveal cardiac side effects of chemotherapic drugs in otherwise healthy patients.