P774Arterial stiffness in patients with heart failure and preserved ejection fraction in 12 month after myocardial infarction


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Abstract

Aim: assess of arterial stiffness in patient with heart failure (HF) and preserved ejection fraction in 12 month after STEMI.Methods: Fifty five pts with HF and preserved ejection fraction (≥45%) in 12 month after STEMI were included in cross-sectional investigation. Average age was 66±9 years. Arterial stiffness was assessed by the tonometry (Sphygmocor, Atcor Medical, Inc.,). Echo exam was performed by the diagnostic system VIVID 7, GE. The levels of BNP and NT-pro BNP were measured.Results: Among enrolled pts 29(53%) were male, 30 (55%) had anterior STEMI 12 month ago, 44(70%) underwent coronary angiography. PCI was performed in 19 (44%) pts, multivessel disease had 27 (61%). The levels of BNP and NT-pro BNP were increased according to functional class of HF. The pulse wave velocity was 10,9±2,77 m/sec. The severity of HF correlated with levels of BNP (R=0,75; p=0,000000) and NT-pro BNP (R=0,67; p=0,000000). Besides interrelation between pulse wave velocity and BNP (R=0,29; p=0,02) and functional class of HF (R=0,39; p=0,003) were revealed. There were no differences in EDV LV, ESV LV, EF LV, WMI, CO and E/A ratio in pts with different functional class of HF. But in E/E' ratio were differences (7,5±1,4; 9,8±5,1; 13,5±7,6 accordingly I, II, III class) depending on severity of HF.Conclusion. The stiffness of the great arteries is increased in pts with HF and preserved left ventricular ejection fraction after STEMI. Combination of increased arterial stiffness, mild disturbances in systolic and diastolic function is pathophysiological basis of HF development in pts with preserved ejection fraction after STEMI.

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