P787Subclinical systolic dysfunction in behcet disease based on tissue Doppler and velocity vector imaging


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Abstract

Background: Behcet' s disease (BD) is a chronic inflammatory disease characterized by recurrent oral and genital ulcerations and ocular lesions. Subclinical cardiac involvement may develop in patients with BD. We aimed to evaluate subclinical left ventricular (LV) and right ventricular (RV) systolic dysfunction in patients with BD, without any cardiovascular disease.Methods : We studied 50 patients with BD (43.8±9.7 years and 59% male) and 30 healthy controls (45.4± 8.2 years and 60% male). Conventional echocardiography, tissue Doppler (TDI) imaging and velocity vector imaging (VVI) based strain imaging were performed to analyze LV and RV systolic functions.Results: Left ventricular isovolumic myocardial acceleration (IVA), peak systolic velocity during isovolumic contraction (IVV) were significantly decreased while myocardial performance index (MPI) was increased in patients with BD . RV peak systolic velocity (Sa), IVA and IVV were markedly reduced in the patient group, also (Table 1). Longitudinal peak systolic strain and strain rate (SRs) of both the LV (14.36±4.30 to 23.98±3.17, p=0.0001 for strain; 0.74±0.33 to 1.52±0.18, p=0.0001 for strain rate) and the RV were significantly impaired (16.14±6.43 to 31.38±2.55, p=0.0001 for strain; 0.58±0.31 to 1.97±0.13, p=0.0001 for strain rate)in patients, compared to controls, demonstrating subclinical ventricular systolic dysfunction.Conclusions: Ventricular long axis functions are important markers of myocardial contractility. Novel echocardiographic techniques may provide additional data for detecting early deterioration in ventricular systolic function in patients with BD.

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