P789Association of sensitive Troponin I and left ventricular contractile function in patients with stable coronary artery disease


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Abstract

Introduction: Studies using sensitive troponin assays have shown that circulating levels below the detection level of conventional assays provide strong and independent prognostic information in patients with heart failure as well as in patients with stable coronary artery disease (CAD) without heart failure. However, the relationship of high sensitive troponin and myocardial function are yet to be defined. We assessed the hypothesis that sensitive cardiac troponin concentrations are associated with left ventricular (LV) contractile function in patients with CAD.Methods: The study population consisted of 161 patients with stable CAD. The concentration of cardiac Troponin I (hsTnI) was determined by highly sensitive assay and was assessed approximately one year after revascularization therapy. LV function was measured as global longitudinal strain by speckle tracking echocardiography. There were no reports on cardiovascular adverse events after the index intervention.Results: When divided into quartiles by level of hsTnI, patients in the highest quartile (9-138 ng/L) demonstrated significantly lower absolute strain values compared with those in the two lowest hsTnI quartiles (-16.5±2.7 % vs. 18.1±2.0 %, P=0.01 and 18.1±2.0 %, P=0.02, respectively) (Figure).Conclusions: Circulating hsTnI is significantly associated with lower left ventricular contractile function in patients with stable coronary artery disease.

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