P838Right and left ventricle function and pulmonary hypertension: Insights from right ventricle dyssynchrony.

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Introduction: PAH induces right ventricular (RV) impairment with left ventricle (LV) interdependence.Objective: Evaluate the relationship between RV dyssynchrony and the systo diastolic function of the RV and LV.Methods: 20 patients, age 65.4±13.5, with PAH on specific therapy, median Nt-ProBNP 730, TAPSE 21.0±5.7, RV ejection fraction 36.7±18.4%, pulmonary artery systolic pressure (PASP) 85.9 ±15mmHg. RV longitudinal global strain (GS) and strain rate, LV papillary muscle (SAX) and apical longitudinal GS determined. RV dyssynchrony characterized by the standard deviation of time-peak systolic in 6 segments (RV lateral wall e LV septum). Relationship between parameters evaluated with Spearman correlation coefficient and linear regression model (backward method).Results (see figure): RV dyssynchrony correlated with: (1) RV function: RV-GS (r= 0.677 p=0.001), RV-GSRs (r=0.594 p=0.006), RV-GSRe (r= -0.594 p=0.006) and V-GSRa (r=-0.577 p=0.019). (2) LV function at SAX level: SAX-GS (r= -0.542 p=0.014), SAX-GSRe (r= 0.484 p=0.03). (3) By multiregression RV dyssynchrony was dependent only on RV-GS (p=0.002) and LV-GS at SAX level (p=0.073)Conclusion: Greater RV dyssynchrony associates with worst RV deformation and apparently better LV deformation, what could be explained an interventricular dependence.

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