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Background: Long standing pulmonary hypertension (PH) causes right ventricular (RV) hypertrophy and dilatation along with abnormal septal motion in order to support the RV pressure overload. With such changes in cardiac function we hypothesize that this pressure overload might induce reduced LV function including LV dyssynchrony.Methods: We investigated 31 patients with PH (pulmonary artery systolic pressure= 59±24 mm Hg) determined by Doppler echocardiography and compared them with 34 healthy controls. We used ACUSON SC2000 Volume Imaging Ultrasound System cardiac ultrasound system equipped with 4Z1c Real-Time Volume Imaging Transducer (Siemens Medical Solutions USA, Inc.Ultrasound Division). We measured RV and LV ejection fraction (RVEF, LVEF), systolic dyssynchrony index (16 segmental model) (SDI) and post-systolic time volume (PSTV).Conclusion: In patients with PH, LV function is significantly affected showing reduced EF, increased intraventricular systolic dyssynchrony and increased post systolic time volume. Although the LV dyssynchrony seems abnormal it is essential for compensating for the partial loss of septal function probably in order to maintain stroke volume.