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Purpose: Speckle tracking has emerged as valuable tool for more comprehensive assessment of regional myocardial function, providing angle-independent measurements of strain. The aim of this study was to evaluate the left ventricular (LV) function in patients with newly diagnosed sarcoidosis, utilizing the novel method of (2D) deformation imaging (strain and torsion).Methods: 26 patients with newly-diagnosed sarcoidosis and without any overt symptoms of cardiovascular disease, as well as 20 healthy age- and gender-matched controls underwent echocardiographic study. In addition to conventional 2D, Doppler and TDI measurements, speckle tracking echocardiography was applied and LV global longitudinal, radial, and circumferential strain was derived from the obtained apical and short axis image acquisitions. Moreover, LV base and apex rotation angles were recorded from which LV torsion was derived.Results: The mean age of patients was 42±6 years old (10 men). Compared with controls, patients had similar conventional 2D and Doppler measurements. TDI revealed increased E/E' in the patient group (8.72 ± 1.65) vs control group (4.6 ± 1.32). Strain analysis in the disease demonstrated higher global longitudinal (21.88 ± 2.18 %) and global circumferential strain (23.71 ± 2.36%) values in the control group vs the patient group(18.86 ± 1.79% and 19.83 ± 3.47% respectively), whereas there was no apparent distinction for radial strain values. Furthermore, torsion was markedly reduced in the patient group (8.3 ± 1.8o) as compared to the healthy individuals (11.5 ± 2.6°).Conclusions: Speckle tracking echocardiography, employing strain and rotational indices may represent a novel method for the early detection of subclinical cardiac involvement in patients with newly-diagnosed sarcoidosis.