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Introduction: Two-dimensional strain (2DS) is a novel method to measure strain from standard two-dimensional echocardiographic images by speckle tracking. Strain imaging has been proposed as tool for the assessment of the left ventricular myocardial function. The aim of our study was to characterize global and regional function abnormalities using this technique in patients (pts) with severe aortic valve stenosis (AS).Methods: We studied 40 consecutive pts with severe AS and comprehensive echocardiographic and hemodynamic assessment. Global longitudinal strain (GLS), regional peak systolic strain (PSS) and strain rate (SR) as well as myocardial velocities (S', E') were assessed by 2DS in the apical four-chamber-view using a dedicated software package called Velocity Vector Imaging (VVI; Siemens, Erlangen, Germany).Results: Mean systolic ejection fraction (EF) was 52±8 %, the echocardiographic mean gradient was 44±15 mmHg, the echocardiographic peak gradient was 76±23 mmHg, and the mean aortic valve area (AVA) was 0.8±0.2 qcm. The results of the VVI analysis are summarized in the table.Conclusion: Quantitative assessment of the global and regional function of the left ventricle demonstrated markedly decreased Strain- and Strain rate values as well as velocities (S', E') in pts with severe AS despite preserved left ventricular function in comparison to controls.