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Introduction: Evaluation for sudden death(SD) risk in hypertrophic cardiomyopathy (HCM) and thus the decision to implant a cardioverter-desfibrillator (ICD) is controversial. Classical risk factors(CRF) are family history of SD, unexplained syncope, left ventricular septal thickness >30mm, nonsustained ventricular tachycardia (NSVT) on Holter and abnormal blood pressure response with exercise. In a previous study, longitudinal strain (Long.S) estimated with speckle tracking correlated with myocardial fibrosis and NSVT presence. Our aim is to describe the relationship between strain and CRF.Methods: We obtained images of the 4, 3 and 2-chamber apical view as well as short axis view in 51 consecutive patients with HCM. For the assessment of longitudinal and radial strain we analyzed 16 segments.Conclusions:Our findings suggest that global and septal Long.S correlate with the presence of several CRF. Patients with at least 1 CRF have diminished Long.S when compared with those free of risk factors. Although it is premature to regard Long.S as a primary risk factor for SD, it may be useful to guide clinical decision-making for prophylactic ICD implantation in borderline patients.