P998Systemic arterial properties in stable heart transplant recipients

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Purpose: Despite high prevalence of cardiovascular diseases in heart transplant recipients (HTx), the properties of the systemic arteries have not been well defined. Thus, the aim of this cross-sectional study was to perform a comprehensive assessment of arterial properties in stable HTx recipients.Methods: 53 stable HTx recipients (age 52 ± 16 years (mean ± SD)) without rejection or cardiac failure were investigated at median 5 years (range 1-17 years) after HTx and compared with healthy age-matched subjects with normal blood pressure or matched to patients by brachial mean arterial blood pressure (MAP-controls). Aortic root pressure and flow data were obtained by semi-simultaneous recordings of aortic root Doppler flow velocities, oscillometrically obtained brachial arterial blood pressure and a calibrated carotid arterial pulse trace. Systemic arterial properties were described by total arterial compliance (C), arterial elastance (Ea), characteristic impedance (Zo), and peripheral vascular resistance (TVR). Parameters were obtained by impedance analysis of central aortic pressure and flow data and by estimation of the parameters of a 2-element windkessel model (pulse pressure method).Results: HTx recipients had significantly lower C compared to the normotensive subjects, and higher Ea compared to both the normotensive subjects and the MAP-controls. No significant differences were found in TVR or Zo between the groups.Conclusions: Systemic arterial properties in HTx differ significantly from normotensive individuals; however only small variations were seen compared to the MAP-control group. Thus, the lower compliance in HTx is likely related to the pressure effect on arterial properties.

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