P999TNF-alpha serum level and left ventricular geometry in hypertensive patients without heart failure


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Abstract

Complex pathogenesis of essential hypertension encompass besides commonly known factors also less extensively studied ones like i.e. tumor necrosis factor alpha (TNF-alpha). This cytokine may be responsible for structural changes in heart muscle such as stimulation of protein synthesis and inhibition of its degradation which leads to myocardial hypertrophy. Moreover, TNF-alpha is an important stimulator of angiotensinogen gene transcription. Hypertensive left ventricular (LV) hypertrophy, especially concentric one, is considered as a strong and independent risk factor of death and other serious cardiovascular complications.The aim of the study was to assess TNF-alpha serum level in hypertensive pts with different types of LV geometry.Methods: The study population consisted of 74 hypertensive pts aged 54±12.2 yrs classified basing on echocardiographic examination into one of 4 types of LV geometry: concentric hypertrophy (CH), eccentric hypertrophy (EH), concentric remodeling (CR) and normal geometry (NG) and 45 healthy subjects serving as control group (CG). Serum measurement of TNF-alpha level was performed by radioimmunometric method.Results: Serum TNF-alpha level in hypertensive pts and controls:CH (n = 22) 14.6 pg/mlEH (n = 14) 15.7 pg/mlCR (n = 21) 13.4 pg/mlNG (n = 17) 12.7 pg/mlCG (n = 45) 14.9 pg/mlThere were no significant differences in serum TNF-alpha level between hypertensive pts and controls, as well as between subgroups with different types of LV geometry.Conclusion: Serum TNF-alpha level in hypertensive pts without heart failure is normal and comparable in pts with different types of LV geometry.

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