Endothelium-dependent and -independent vasodilation is more attenuated in ischaemic than in non-ischaemic heart failure


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Abstract

AimsEndothelial dysfunction in chronic heart failure (CHF) contributes to vasoconstriction. Underlying atherosclerosis may increase vascular abnormalities in ischaemic CHF. We aimed to compare flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD) of the brachial artery between patients with ischaemic and non-ischaemic CHF.Methods and resultsA total of 57 patients with systolic CHF participated in the study (mean age 59 ± 8 years, 81% male). Patients were in stable NYHA class II (40 patients, 70%) and III (17 patients, 30%). Ischaemic aetiology of CHF was confirmed by coronary angiography in 34 (60%) patients and ruled out in 23 (40%). Flow-mediated dilation and NMD of the brachial artery was assessed by high-resolution ultrasound. Endothelium-dependent vasodilation was markedly reduced in patients with ischaemic CHF compared with those with non-ischaemic aetiology of CHF—mean absolute change in artery diameter (Δd) 0.09 ± 0.07 mm in ischaemic group vs. 0.18 ± 0.07 mm in non-ischaemic (P < 0.0001). Nitroglycerin-mediated vasodilation was also significantly different—Δd=0.14 ± 0.06 mm in ischaemic vs. 0.31 ± 0.10 mm in non-ischaemic CHF (P < 0.0001).ConclusionEndothelium-dependent and -independent vascular response is more attenuated in ischaemic than in non-ischaemic CHF.

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