The prognostic importance of lung function in patients admitted with heart failure


    loading  Checking for direct PDF access through Ovid

Abstract

AimsThe purpose of the present study was to determine the prognostic importance for all-cause mortality of lung function variables obtained by spirometry in an unselected group of patients admitted with heart failure (HF).Methods and resultsThis was a prospective prognostic study performed as part of the EchoCardiography and Heart Outcome Study (ECHOS). This analysis included 532 patients admitted with a clinical diagnosis of HF. All patients underwent spirometry and echocardiography and the diagnosis of HF was made according to established criteria. Mean forced expiratory volume in 1 s (FEV1) was 65% of the predicted value [95% confidence interval (CI) 63–67%], mean forced vital capacity (FVC) was 71% of predicted (95% CI 69–72%), and FEV1/FVC was 0.72 (95% CI 0.71–0.73). FEV1, FVC, and FEV1/FVC were all significant prognostic factors for all-cause mortality in univariate analyses. In a multivariate analysis, FEV1 had independent prognostic value (hazard ratio 0.86 per 10% change, P < 0.001) after adjusting for demographic variables, known risk factors, ejection fraction, and self-reported chronic obstructive pulmonary disease.ConclusionPulmonary function provides significant prognostic information for all-cause mortality in patients admitted with HF. Spirometry therefore seems to be worth considering for all patients admitted with HF in order to identify patients at high risk.

    loading  Loading Related Articles