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The aim of the study was to assess pre-treatment cephalometric parameters and measurements of the size of the apical bases as predictors of successful orthodontic correction of Class III malocclusions.Pre- and post-treatment lateral cephalograms and study models of 80 completed Class III subjects were examined to obtain 23 cephalometric parameters taken mainly from the analyses of McNamara and Schwarz, and to measure the size of the apical bases. Success of occlusal correction was evaluated as the percentage change of peer assessment rating score during treatment, which was used as the dependent variable in multivariate statistical analyses testing the predictive value of the parameters assessed.No improvement in the Class III skeletal pattern occurred during treatment and the treatment effects were confined to dentoalveolar changes. With the exception of the percentage midfacial length/mandibular length ratio, the net sum of maxillary and mandibular length differences, the mandibular ramus height/mandibular body length ratio and the gonion angle, most cephalometric parameters of pre-treatment craniofacial morphology assessed were poor predictors of successful correction of Class III malocclusions. Assessment of the size relationship of the maxillary and mandibular apical bases was the strongest predictor of occlusal correction achieved and may serve as a valuable diagnostic addition in the prediction of successful treatment outcome.