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The aim of this study was to investigate the in vivo bonding of orthodontic brackets using two resin-modified glass poly(alkenoate) cements and to compare them with a conventional light-cured diacrylate bonding agent.Twenty consecutive patients attending for bond up appointments took part in this randomized cross-mouth control study. Alternate quadrants were bonded with either Fuji Ortho LC or 3M Multi-Cure. Transbond [Adhesive Pre-Coated Brackets (APC™)] acted as the control in the other quadrants. Failed brackets were rebonded with the same material. Bond failure rates were collected over a 1-year period.The bond failure rates over 1 year were 7.2 per cent for Transbond (APC), 5.9 per cent for 3M Multi-Cure, and 5.8 per cent for Fuji Ortho LC. Statistically, there was no significant difference between the bond failure rates of the materials and there was no effect of time.This clinical investigation confirmed the suitability of the resin-modified glass poly(alkenoate) cements under test as orthodontic bonding agents.