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The aim of this compound cephalometric and arch-width study was to determine any dental and/or skeletal differences between subjects with Class II division 1 and Class II division 2 malocclusions. The dento-skeletal characteristics of Class II subjects were evaluated using lateral cephalometric radiographs and dental casts of 90 untreated patients. The sample included 46 Class II division 1 patients (19 girls and 27 boys) with a mean age of 15.27 ± 2.48 years, and 44 Class II division 2 patients (27 girls and 17 boys) with a mean age of 15.95 ± 3.25 years. The intermolar, interpremolar and intercanine measurements were carried out on study models. The radiographs were digitized and processed using Dolphin Imaging software. In addition to standard descriptive statistical calculations, an independent samples t-test was carried out in order to compare the two groups. The non-parametric Mann–Whitney U test was utilized for the parameters for the data which were not normally distributed.The only statistically significant difference between the groups for the study model measurements was mandibular intercanine width. The cephalometric results revealed that SNB angle was responsible for the skeletal sagittal difference between the two groups. In addition, the Class II division 1 group had higher vertical proportions and the Class II division 2 group a more concave profile with a prominent chin. The sagittal skeletal pattern of Class II division 2 subjects was found to be very similar to the Class I skeletal relationship, with no evidence of any mandibular restriction.