Diffusion MRI and spectroscopy in Rasmussen's encephalitis

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Abstract.The purpose of this study was to evaluate the diffusion MRI and proton MR spectroscopy findings in a rare disorder, Rasmussen's encephalitis. Diffusion MRI studies of 3 cases of Rasmussen's encephalitis were performed using the echo-planar trace sequence (TR=5700 ms, TE=139.03 ms). The gradient-echo diffusion sequence, PSIF (TR=21.6 ms, TE=5 ms), which is a reverse FISP sequence, and proton MR spectroscopy (TR=1500 ms, TE=40 ms) were applied in two patients. The trace sequence revealed high apparent diffusion coefficient values at the diseased regions (1.21±0.13×10-3 mm2/s), compared with normal parenchymal values in 12 control cases (0.84±0.09×10-3 mm2/s), indicating increased motion of water molecules (disintegration of the tissue) in these regions. The PSIF sequence revealed pixel value differences between the two hemispheres. Proton MR spectroscopy revealed decreased N-acetyl aspartate peaks, compared with five control cases.

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