Uncontrolled Randomized Clinical Trial Demonstrates Similar Long-Term (6 months) Antigingivitis and Antiplaque Efficacy for 2 Mouth Rinses: One that Uses Cetylpyridinium Chloride (CPC) as an Active Agent and the Other that Uses Essential Oils (EO) as an Active Agent

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ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATIONComparison of the effects of cetylpyridinium chloride with an essential oil mouth rinse on dental plaque and gingivitis—a six-month randomized controlled clinical trialAlbert-Kiszely A, Pjetursson BE, Salvi GE, Witt J, Hamilton A, Persson GR, et al.J Clin Periodontol 2007;34(8):658-67LEVEL OF EVIDENCE2PURPOSE/QUESTIONThe purpose of this study was to compare the long-term (6 months) clinical and microbiological effects of an experimental CPC mouth rinse with that of a commercially available and widely used EO mouth rinse in an unsupervised, uncontrolled 6-month randomized clinical trial.SOURCE OF FUNDINGThis study was supported by a grant from the manufacture of the experimental CPC mouth rinse, Procter & Gamble Company (Mason, OH), and by the Clinical Research Foundation (CRF) for the Promotion of Oral Health, University of Berne, Switzerland.TYPE OF STUDY/DESIGNThis is a parallel randomized 2-group study that had no negative control.

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