Psychological Characteristics Such as Depression, Independent from a Known Genetic Risk Factor, Increase the Risk of Developing Temporomandibular Disorder Pain

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ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATIONInfluence of psychological factors on risk of temporomandibular disorders.Slade GD, Diatchenko L, Bhalang K, Sigurdsson A, Fillingim RB, Belfer I, et al.J Dent Res 2007;86(11):1120-5.LEVEL OF EVIDENCELevel 1 (Good quality, patient-oriented evidence)STRENGTH OF RECOMMENDATION GRADEGrade B (Inconsistent or limited-quality patient-oriented evidence)PURPOSE/QUESTIONThe authors aimed to answer 4 questions:Is sensitivity to standardized noxious stimuli (perceived usually as painful) predictive of TMD risk?What psychological characteristics are associated with pain sensitivity?Are those same psychological characteristics predictive of TMD risk?Is the magnitude of TMD risk associated with those psychological factors attenuated after adjustment for variants of the gene encoding COMT?SOURCE OF FUNDINGMultiple grants from the National Institutes of Health, US Government.TYPE OF STUDY/DESIGNSmall Cohort Study

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