The paths from research to improved health outcomes
Carvedilol reduced mortality and hospital admission in severe chronic heart failure, regardless of pretreatment systolic BP
Review: hormone therapy may reduce the risk of death in younger but not older postmenopausal women
Topically applied imiquimod 5% cream cleared actinic keratosis lesions
Review: fluoxetine, orlistat, and sibutramine modestly reduce weight in type 2 diabetes
Review: orlistat and sibutramine are modestly effective for weight loss at 1 year
Ginger was equivalent to pyridoxine hydrochloride (vitamin B6) for reducing nausea and vomiting in pregnancy
Long term donepezil did not delay institutionalisation or progression to disability in patients with Alzheimer’s disease
Review: anticonvulsants are better than placebo for reducing the frequency of migraine attacks
Review: sedative hypnotic agents reduce mortality and duration of delirium in the alcohol withdrawal syndrome
Smoking reduction with nicotine replacement and motivational advice reduced smoking in people unmotivated to quit
Review: clonidine is more effective than placebo for long term smoking cessation, but has side effects
Review: corticosteroids do not reduce hospital length of stay or respiratory distress in infantile acute viral bronchiolitis
Review: data are lacking on the effect of bed rest in women with singleton pregnancies who are at high risk of preterm birth
Below knee elastic compression stockings reduced development of the post-thrombotic syndrome in proximal deep venous thrombosis
Review: intra-articular corticosteroid injections are better than placebo for improving symptoms of knee osteoarthritis
Review: capillary refill time, abnormal skin turgor, and abnormal respiratory pattern help to detect dehydration in children
Review: point of care dipstick urinalysis has low accuracy for detecting proteinuria in pregnancy
Review: sensitivity of the CAGE questionnaire for the DSM diagnosis of alcohol abuse and dependence in general clinical populations was 71% at cut points ≥2
A positive result on both the Paxinos test and bone scan ruled in a diagnosis of acromioclavicular joint pain
Loop diuretics and angiotensin converting enzyme inhibitors increased risk of hospital admission for lithium toxicity
Tramèr MR. Evidence-based resource in anaesthesia and analgesia. 2nd edition. London: BMJ Books, 2003.
Hunink M, Glasziou P, Siegel J, et al. Decision making in health and medicine. Integrating evidence and values. Cambridge: Cambridge University Press, 2001.
Other articles noted