Purpose and procedure
New look Evidence-Based Medicine
Simple physical interventions such as hand washing and wearing masks can reduce spread of respiratory viruses
Combined educational and contraceptive interventions reduce unplanned teenage pregnancy, but how useful is this finding for policy and practice?
Feedback to internal medicine ward physicians from multidisciplinary antimicrobial use teams improves appropriate antimicrobial use
No difference between short-course and long-course antibiotics for bacterial meningitis in children, but available evidence limited
High efficacy of HPV 16/18 AS04-adjuvanted vaccine shown against CIN2+ associated with HPV-16/18 and non-vaccine oncogenic HPV types
Use of inhaled budesonide for 1 year does not increase risk of pneumonia in patients with chronic obstructive pulmonary disease
“Hospital at home” care shows similar mortality and subsequent hospital admissions to hospital care for older patients with acutely decompensated chronic heart failure
Healthcare assistant case management may reduce depression symptoms in primary care patients with major depression more than usual care
Induction of labour improves maternal outcomes compared with expectant monitoring in women with gestational hypertension or mild pre-eclampsia
Immediate colposcopy referral in women with low-grade abnormal results on cervical cytology detects more CIN2 or worse lesions than cytological surveillance in primary care, but might lead to overtreatment
Effects of physical fitness training on mortality, independence and disability after stroke unclear
Antipyretic drugs do not reduce recurrences of febrile seizures in children with previous febrile seizure
Interactive booklet reduces antibiotic prescribing for respiratory tract infections in children, but not parent satisfaction
Web-based screening and brief motivational intervention reduces alcohol use in heavy-drinking undergraduates at up to 6 months
Preventive antibiotics reduce infections but not mortality in adults with acute stroke
Adding atypical antipsychotics to antidepressants increases response in treatment-resistant major depression but increases discontinuation as a result of adverse events
Neuraminidase inhibitors produce a small reduction in duration of seasonal influenza in children and reduce transmission in affected households, but effects on serious complications unclear
Knee strengthening exercises at home, but not dietary intervention, reduce knee pain and improve knee function in overweight and obese people over 2 years
Primary care screening and brief counselling for overweight or mildly obese children does not improve BMI, nutrition or physical activity
Corticosteroids added to antibiotic therapy aid pain resolution in adults with sore throat, particularly severe or exudative sore throat
Cochrane Review highlights the need for more targeted research on the tolerability of malaria chemoprophylaxis in travellers
No difference in peak troponin level in immediate versus delayed (next working day) intervention for acute coronary syndrome without ST-segment elevation
Point-of-care D-dimer tests can contribute to patient management in outpatients with suspected venous thromboembolism, particularly those at low risk
GPs good at ruling out depression in primary care, but false positives common
Aspirin for primary prevention of cardiovascular disease?