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Making GRADE accessible
A 3-year lifestyle intervention for adults at moderate to high risk of cardiovascular disease is cost effective when added to standard care and improves physical health-related quality of life
Extended colonic release low-molecular weight heparin (LMWH) not ready for use in ulcerative colitis
Percutaneous coronary intervention for acute coronary syndrome
In people with severe aortic stenosis unsuitable for surgery transcatheter aortic valve implantation reduces 1-year mortality compared with standard care
Tricyclic antidepressants reduce frequency of tension-type and migraine headaches compared with placebo, and intensity of headaches compared with SSRIs, but cause greater adverse effects
Combined prophylactic β-blocker and behavioural migraine management improves 30-day migraine outcomes compared with either strategy alone, or optimised acute treatment only
A decision aid to enhance informed decision making about bowel cancer screening improved knowledge but reduced screening uptake
Chinese acupuncture for chronic shoulder pain
Percutaneous coronary intervention for acute coronary syndromes
Repeated dosing of nebulised 5% saline improves respiratory scores in inpatients with mild to moderate bronchiolitis at 48 h
Evidence from two small randomised controlled trials suggests that probiotics may reduce the duration of persistent diarrhoea in children
A programme of culturally tailored dance plus an intervention to reduce screen media use does not reduce BMI over 2 years compared with health education in preadolescent low-income African American girls but does reduce depressive symptoms and lipid levels
Symptomatic carotid stenosis
Morning-only polyethylene glycol preparation for afternoon colonoscopy is superior to traditional evening-before preparation
Several clinical signs and symptoms are associated with the likelihood of bacterial meningitis in children; the most reliable diagnostic combination is uncertain
Prospective studies show that magnetic resonance angiography has high sensitivity and specificity for clinically relevant arterial steno-occlusions in adults with peripheral arterial disease symptoms
Ultrasound scan for suspected appendicitis in children
Pregnancy-related cardiac risk in women with congenital heart disease
Mortality is reduced while on opiate maintenance treatment, but there is a temporary increase in mortality immediately after starting and stopping treatment, a finding that may vary by setting
Automated external defibrillator use for in-hospital cardiac arrest is not associated with improved survival
Purpose and procedure