Hydroxycarbamide for very young children with sickle cell anaemia
Randomised trial of radical prostatectomy versus watchful waiting finds reduced risk for death but uncertainty still reigns
Systematic review of observational studies finds increased risk of fracture among older adults taking a proton pump inhibitor
Oxygen may reduce dyspnoea in people with COPD who have mild or no hypoxaemia
The administration of corticosteroids to 34–36-week pregnant women at risk of imminent delivery does not reduce the risk of respiratory disorders in the newborn
Cardiac resynchronisation therapy reduces mortality in patients with heart failure but questions remain
In two parallel pragmatic equivalence trials, leukotriene receptor antagonists as initial therapy for asthma compared with inhaled corticosteroids and as add on therapy to ICS compared with adding long-acting β agonists provided equivalent short-term asthma quality of life but were associated with more medication switches
Early (at 34–35 weeks) external cephalic version reduced the risk of non-cephalic (breech) presentation at birth but has no effect on risk of caesarean section
Warming local anaesthetic prior to injection reduces injection pain
Ovarian cancer screening has no effect on disease-specific mortality
A 2-year early childhood psychosocial stimulation programme improves cognitive outcomes and decreases violent behaviour at 22 years for children with growth retardation
Cohort analysis finds that the proportion of people who meet high risk criteria for colorectal, breast or prostate cancer screening based on family history increases between age 30 and 50
Management of patients hospitalised with community-acquired pneumonia
In patients hospitalised with acute heart failure, nesiritide, compared with placebo, is not associated with improvements in dyspnoea or 30-day rehospitalisation or mortality
In selected lower risk patients with acute pulmonary embolism, outpatient treatment is not associated with increased risk of adverse outcomes compared with standard inpatient care
Intensive statin therapy, compared with moderate dose, increases risk of new onset diabetes but decreases risk of cardiovascular events
Sensitivity of pulse oximetry for detection of critical congenital heart defects in newborn infants higher than that of antenatal ultrasound with few false positives
Hammering the point home
Inhaled anticholinergic medications in older men with chronic obstructive pulmonary disorder are associated with increased odds of acute urinary retention
Short- and long-term treatment with non-steroidal anti-inflammatory drugs increases risk of death or recurrent MI in those with previous MI
Modelling study of prognostic indicators for patients with locally advanced or metastatic cancer identifies variables that predict short-term survival in palliative care
Enhancing the Framingham Risk Score for coronary heart disease by adding information on working hours
Modifiable risk factors for stillbirth in high-income countries include overweight and obesity, maternal age and smoking
Babies exposed to newer-generation antiepileptic drugs (compared with no antiepileptic drug exposure) in the first-trimester of pregnancy are not at increased risk of major birth defects
Book review
Purpose and procedure