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Suggestions for improving guideline utility and trustworthiness
Reporting quality of diagnostic accuracy studies
Success rates of abdominal sacrocolpopexy decrease over time, but with improved continence rates with concomitant urethropexy
Central venous catheters coated or impregnated with antimicrobial agents effectively prevent microbial colonisation and catheter-related bloodstream infections
A 5-day course of systemic corticosteroids is adequate to treat acute exacerbations of chronic obstructive pulmonary disease
Aspirin plus clopidogrel in acute minor ischaemic stroke or transient ischaemic attack is superior to aspirin alone for stroke risk reduction
Plastics bags reduce hypothermia in newly born infants in the developing world
Does treatment of depression in ageing populations decrease risk of mortality?
Cardiovascular benefits of HRT may differ by patient age
Symptoms of obstructive sleep apnoea are treated by adenotonsillectomy, but without change in neurocognitive outcome
Central venous pressure cannot predict fluid-responsiveness
Modest weight loss does not decrease cardiovascular morbidity and mortality in adults with type 2 diabetes
Respiratory syncytial virus prophylaxis reduces chronic respiratory morbidity in prematurely born infants
Amniotomy has no effect on shortening of spontaneous labour
An interferon-free, all-oral regimen is effective in treatment of genotype 1 chronic HCV infection
Statin potency associated with incident diabetes in a real-world evaluation
Healthy women with a normal singleton pregnancy at term are not likely to be harmed by planning a home birth
Practice and progress in obstetrics
Maternal obesity is an independent risk factor for spontaneous extremely preterm delivery
Antidepressant exposure in utero is associated with an increased risk of cardiovascular malformation
Perioperative selective serotonin reuptake inhibitor administration is a marker of poor outcomes after surgery
Ibuprofen does not seem to increase global malformation risk but NSAID use in late pregnancy remains a concern
Prothrombin complex concentrate safely reverses warfarin-related bleeding
Meta-analysis
Cognitive impairment is a major risk factor for serious hypoglycaemia; public health intervention is warranted
Stimulant medication for ADHD not associated with subsequent substance use disorders
Peripartum antidepressant use is associated with an increased risk of postpartum haemorrhage
Estimating the cost-effectiveness of modern screening mammography programmes
The risk of low-to-moderate prenatal alcohol exposure on child academic underachievement and behaviour may be difficult to measure and should not be underestimated
Beyond genetics
Combined diet and exercise interventions can improve metabolic outcomes in obese children, even with only small changes in weight
Individual clinical symptoms have limited utility in the diagnosis of obstructive sleep apnoea
Risk of venous thrombosis varies with different types of combined oral contraceptives
Tranexamic acid reduces surgical bleeding
Current evidence for ART practice
Gastric bypass surgery is more efficacious than intensive lifestyle and medical treatment for type 2 diabetes remission
Systematic review suggests TNF-α inhibitors may be rational options for pregnant patients with inflammatory bowel disease
Abnormal vaginal bleeding after epidural steroid injection