Peer review of human studies run amok: a break in the fiduciary relation between scientists and the public
Harms of CT scanning prior to surgery for suspected appendicitis
Naloxegol increases frequency of bowel movements and combats inadequate response to laxatives
ABT-450/r-ombitasvir and dasabuvir with ribavirin eliminates viraemia in most patients with HCV infection with cirrhosis
Zanamivir for influenza in adults and children shows limited benefit for treatment of symptomatic influenza and no effect on relevant complications
Effects of screening and lifestyle counselling on incidence of ischaemic heart disease in general population are limited
Phase 3 trial with the RTS,S/AS01 malaria vaccine shows protection against clinical and severe malaria in infants and children in Africa
Antithrombotic therapy for pregnancy complications: let's not throw the baby out with the bath water
Updated review identifies no adverse impact on mother or offspring during the perinatal period of aspirin use for prevention of preeclampsia
With statin co-administration, drugs designed to increase HDL have no impact on cardiovascular outcomes
Calcaneal fractures have universally poor outcomes regardless of management
Fruit and vegetable consumption is associated with reduced all-cause and cardiovascular mortality
Delaying initiation of ART for 5 weeks improves survival in patients with HIV infection with cyrptococcal meningitis
Epidural steroid injections are not effective for patients with lumbar spinal stenosis
Initial choice of medication has little effect on short-term or long-term outcome for most patients with Parkinson's disease
Gastric bypass has better long-term outcomes than gastric banding
Pulse oximetry may lead to unnecessary hospital admissions for infants with bronchiolitis and mild hypoxaemia
Collaborative care improves clinical outcomes for adolescents with depression treated in primary care
Blood pressure-lowering treatment should be based on the level of cardiovascular risk, not on the level of blood pressure
Gum chewing is associated with early recovery of bowel motility and shorter length of hospital stay for women after caesarean section
Treatment of hepatitis C, then, now and tomorrow
The therapeutic value of hypertonic saline in acute bronchiolitis remains unclear
For patients who underwent elective non-cardiac surgery, a history of stroke is associated with an increased risk of major adverse cardiovascular events and death, particularly if time elapsed between stroke and surgery is less than 9 months
Aiming too high or too low? Searching for the appropriate therapeutic thresholds in hypertension is not over yet
The unprecedented scale of the West African Ebola virus disease outbreak is due to environmental and sociological factors, not special attributes of the currently circulating strain of the virus
Long-term follow-up after removal of colorectal adenomas provides evidence for risk stratification of patients at colonoscopic polypectomy
Study results suggest a positive effect of light-to-moderate physical activity on disability among those with or at risk of knee arthritis
Evidence is lacking to support pelvic examinations as a screening tool for non-cervical cancers or other conditions
CT should not be relied on for cases of isolated vomiting in children with blunt head trauma
Physician practice and PECARN rule outperform CATCH and CHALICE rules based on the detection of traumatic brain injury as defined by PECARN
Pertussis: a significant cause of prolonged acute cough in previously vaccinated school-aged children
Risk of warfarin-associated intracerebral haemorrhage after ischaemic stroke is low and unchanged during the 2000s
Potential confounding still clouds the possible association of maternal caffeine intake and low birth weight
Mendelian randomisation meta-analysis sheds doubt on protective associations between ‘moderate’ alcohol consumption and coronary heart disease
Low-dose opioids should be considered for symptom relief also in advanced chronic obstructive pulmonary disease (COPD)
Response to Ekström et al regarding low-dose opioids in advanced chronic obstructive pulmonary disease