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Clinicians should think twice before prescribing DPP-4 inhibitors for diabetes
Lumacaftor-ivacaftor (Orkambi) for cystic fibrosis
Filtered sunlight reduces serum bilirubin levels as effectively as conventional phototherapy in late preterm and term neonates with mild jaundice
Cardiac resynchronisation therapy with an implantable cardioverter defibrillator appears to be cost-effective in patients with mild heart failure
Appropriate design, methodological quality assessment, and clinically relevant outcomes are essential to determine the therapeutic role of epidural injections for low back pain and radiculopathy
Drug-eluting stents and drug-eluting balloons are the best strategies to treat coronary in-stent restenosis
Revascularisation plus supervised exercise is superior to supervised exercise alone for the treatment of intermittent claudication
Both paroxetine and imipramine appear to be ineffective in adolescents with major depression, furthermore doubts have risen about their safety
In newborns, oral or rectal paracetamol fails to reduce procedural pain, whereas intravenous paracetamol reduces morphine requirements after major surgery
Antenatal dietary education and/or balanced nutritional supplementation benefits at-risk women and infants
Limited data suggest that otherwise healthy school-aged children with obstructive sleep disordered breathing have some benefit from adenotonsillectomy compared with non-surgical treatment
New reversal agent for factor Xa inhibitors shows promise
Prophylactic tranexamic acid in addition to uterotonics may prevent blood loss for vaginal and caesarean deliveries
Many US adults with controlled type 2 diabetes receive frequent HbA1c testing and possible overtreatment
Antiretroviral pre-exposure prophylaxis for HIV prevention is highly effective in community settings
High-sensitivity troponin predicts coronary disease outcomes in type 2 diabetes but yields no benefit in selecting patients for revascularisation
In hypertensive patients with elevated risk of cardiovascular disease, targeting systolic blood pressure to less than 120 mm Hg significantly reduces the rate of fatal and non-fatal cardiovascular events as well as death from any cause
Treatment for chronic Strongyloides stercoralis infection
No new evidence to support the routine use of steroids in the treatment of infectious mononucleosis
Detemir is non-inferior to NPH insulin in women with pregestational type 2 diabetes and gestational diabetes mellitus
Adjunctive use of intrapartum foetal ST-segment analysis (STAN) confers no benefit over conventional foetal heart rate monitoring
Insomnia is associated with risk of future cardiovascular events irrespective of comorbidities
Higher coffee consumption is associated with lower risk of all-cause and cause-specific mortality in three large prospective cohorts
Fidgeting is associated with lower mortality risk
The combination of maternal early pregnancy characteristics and current antenatal blood pressure measurement from 28 weeks’ gestation improves the prediction of women at risk of developing pre-eclampsia
Fetal-neonatal iron deficiency is associated with poorer auditory recognition memory at 2 months of age
Influenza vaccination and egg allergy
Preoperative treatment with β-blockers is associated with elevated postoperative mortality and cardiac morbidity in patients with uncomplicated hypertension undergoing non-cardiac surgery
Pertussis has low prevalence in adults with acute cough and is difficult to distinguish clinically from other causes
Clinical judgment is not passé when it comes to identifying patients with acute myocardial infarction
High prevalence of depression in medical residents
Why doctors should convey the medical consensus on vaccine safety
Response to commentary by D Roth