Pyramids are guides not rules
EBHC pyramid 5.0 for accessing preappraised evidence and guidance
New evidence pyramid
Low-density lipoprotein cholesterol goals
Ovarian cancer screening
Natural language processing
Interpreting meta-analysis of continuous outcomes with pre and postvalues
Expectant management with close monitoring of mother and neonate should be practised after late preterm prelabour rupture of membranes
Physical, nutritional, cognitive and combination interventions reduce frailty in community-dwelling prefrail and frail older people
Nebulised hypertonic saline may be less effective than previously reported in reducing hospital length of stay and admission rate in acute bronchiolitis
In H. pylori- infected patients second-line treatment with sequential levofloxacin therapy was more effective than levofloxacin triple therapy but was still suboptimal
Short-term health and social care benefits of the Family Nurse Partnership lack evidence in the UK context but there is promise for child developmental outcomes
Dihydroartemisinin–piperaquine holds promise as an option for malaria prevention in pregnancy
Earplugs might reduce intensive care unit delirium but quality of evidence is low
Fusion in degenerative spondylolisthesis becomes controversial…again
Using a multiplier of 10-year cardiovascular mortality underestimates cardiovascular risk in younger individuals and women
Aortic events in patients with thoracic aortic aneurysms may be underestimated
Restarting oral anticoagulation among patients with atrial fibrillation with gastrointestinal bleeding was associated with lower risk of all-cause mortality and thromboembolism
Smoking cessation improves Crohn's disease outcomes regardless of the use of anti-TNF or immunomodulator
Risk of vascular events is lower than expected in patients with transient ischaemic attack or minor stroke treated promptly by stroke specialists
Early detection of hearing impairment reflected in better reading ability in teenage years
Study raises new doubts regarding the hypothesised health benefits of ‘moderate’ alcohol use
Study finds little impact of hydrolysed formula on risk of allergic disease, but study methods may limit conclusions and generalisability
Physicians frequently fail to de-intensify treatment in older patients with diabetes and very low haemoglobin A1c or blood pressure
Large ovarian cancer screening trial shows modest mortality reduction, but does not justify population-based ovarian cancer screening
Radiation risk due to CT diagnostics of acute appendicitis
Response to letter from Professor Tapio Vehmas