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Women are victims of cardiovascular disease (CVD) at rates similar to men. A reduction in CVD within developed nations has been noted and is primarily due to preventive efforts focused on risk factor modification. Middle- and low-income nations, however, have noted an increase in CVD. Efforts to reduce the occurrence of CVD risk factors targeting women's health in these populations are lacking and need to be encouraged. Risk factor modification with regards to hypertension, dyslipidemia, diabetes, tobacco use, abdominal obesity and psychosocial factors would provide the greatest reduction in CVD occurrence.