Coronary Smooth Muscle and Endothelial Adaptations to Exercise Training

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Exercise training produces complex changes in intrinsic control of coronary vascular resistance. In smooth muscle, adaptations that alter Ca2+ regulation seem central, including changes in the function of sarcolemmal K+ and L-type Ca2+ channels and the sarcoplasmic reticulum. Exercise training also increases the ability of the endothelium to release vasoactive factors, with increased expression and activity of endothelial cell nitric oxide synthase playing a key role.

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