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The aim of this study was to examine the relation between phase angle (PhA) and inflammatory and oxidative stress biomarkers in older women.One hundred and fifty-five physically independent older women participated in this study (67.7 ± 5.7 years, 27.0 ± 4.4 kg/m2). Inflammatory markers included interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and acute phase reactive protein (CRP). Oxidative stress biomarkers comprised superoxide dismutase (SOD), catalase (CAT), advanced oxidation protein products (AOPP), and total radical-trapping antioxidant potential (TRAP). A spectral bioelectrical impedance device was used to estimate resistance (R) and reactance (Xc) at frequency 50 kHz, and subsequently PhA was calculated as arc-tangent (Xc / R) × 180° / π. The covariates appendicular lean soft-tissue (ALST), trunk fat mass, and total body fat were determined by whole-body dual-energy X-ray absorptiometry. Linear regression analysis was conducted to further test if PhA is related with the dependent variables, after adjusting for potential covariates.After controlling for the potential covariates (age, trunk fat mass, ALST, and number of diseases) PhA exhibited a significant inverse relation with IL-6 (β = −0.97; P < 0.01), TNF-α (β = −0.84; P < 0.01), and CRP (β = −0.58; P < 0.01). Conversely, PhA was significantly related to CAT (β = 7.27; P < 0.01), SOD (β = 10.55; P < 0.01) and TRAP (β = 73.08; P < 0.01). The AOPP did not demonstrate a significant correlation with PhA (P > 0.05).Our findings show that PhA is a simple and relevant explanatory variable which is related inflammatory and stress oxidative markers in physically independent older women, regardless of age, number of diseases, and body composition.Phase Angle is inversely related to inflammatory biomarkers (IL-6, TNF-α, and CRP) in older women.Phase Angle is positively related to antioxidant enzymes (SOD and CAT) and the total radical-trapping antioxidant (TRAP)Phase Angle could be a useful tool to predict inflammatory and stress oxidative markers in older women.