This study compared the effects of 12weeks of high-intensity interval body weight training (HIBWT) with combined training (COMT; aerobic and resistance exercises on body composition, a 6-minute walk test (6MWT; physical performance), insulin resistance (IR) and inflammatory markers in postmenopausal women (PW) at high risk of type 2 diabetes mellitus (TDM2).Methods:
In this randomized controlled clinical study, 16 PW at high risk of TDM2 were randomly allocated into two groups: HIBWT (n=8) and COMT (n=8). The HIBWT group performed a training protocol (length time ˜28min) consisting of ten sets of 60s of high intensity exercise interspersed by a recovery period of 60s of low intensity exercise. The COMT group performed a training protocol (length time ˜60min) consisting of a 30min walk of moderate intensity following by five resistance exercises. All training sessions were performed in the university gym facility three days a week (no consecutive days) for 12weeks. All outcomes (body composition, muscle function, and IR and inflammatory markers) were assessed at the baseline and at the end of the study.Results:
Both groups increased (P<0.05) muscle mass index (MMI), 6MWT, and interleukin 1 receptor antagonist and decreased fasting glucose, glycated hemoglobin, Insulin, HOMA-IR, and monocyte chemoattractant protein-1 (trend, P=0.056). HIBWT effects were indistinguishable (P>0.05) from the effects of COMT. There was a significant (P<0.05) interaction of time by the group in muscle strength, indicating that only the COMT increased the muscle strength.Conclusions:
This study suggests that changes in HOMA, IL-1ra, 6MWT, and MMI with HITBW are similar when compared to COMT in PW at high risk of TDM2.Conclusions:
Trial registration: The patients were part of a 12-week training study (ClinicalTrials.gov Identifier: NCT03200639).