High-intensity body weight training is comparable to combined training in changes in muscle mass, physical performance, inflammatory markers and metabolic health in postmenopausal women at high risk for type 2 diabetes mellitus: A randomized controlled clinical trial
Fernanda Martins;Aletéia de Paula Souza;Paulo Nunes;Márcia Michelin;Eddie Murta;Elisabete Resende;Erick de Oliveira;Fábio Orsatti;
aExercise Biology Research Group (BioEx), Federal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais, BrazilbDepartment of Sport Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais, BrazilcResearch Institute of Oncology (IPON) and Gynecology and Obstetrics course, Federal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais, BrazildSchool of Medicine, Federal University of Uberlandia, Uberlandia, MG, Brazil
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Objective:This study compared the effects of 12weeks of high-intensity interval body weight training (HIBWT) with combined training (COMT; aerobic and resistance exercises on body composition, a 6-minute walk test (6MWT; physical performance), insulin resistance (IR) and inflammatory markers in postmenopausal women (PW) at high risk of type 2 diabetes mellitus (TDM2).Methods:In this randomized controlled clinical study, 16 PW at high risk of TDM2 were randomly allocated into two groups: HIBWT (n=8) and COMT (n=8). The HIBWT group performed a training protocol (length time ˜28min) consisting of ten sets of 60s of high intensity exercise interspersed by a recovery period of 60s of low intensity exercise. The COMT group performed a training protocol (length time ˜60min) consisting of a 30min walk of moderate intensity following by five resistance exercises. All training sessions were performed in the university gym facility three days a week (no consecutive days) for 12weeks. All outcomes (body composition, muscle function, and IR and inflammatory markers) were assessed at the baseline and at the end of the study.Results:Both groups increased (P<0.05) muscle mass index (MMI), 6MWT, and interleukin 1 receptor antagonist and decreased fasting glucose, glycated hemoglobin, Insulin, HOMA-IR, and monocyte chemoattractant protein-1 (trend, P=0.056). HIBWT effects were indistinguishable (P>0.05) from the effects of COMT. There was a significant (P<0.05) interaction of time by the group in muscle strength, indicating that only the COMT increased the muscle strength.Conclusions:This study suggests that changes in HOMA, IL-1ra, 6MWT, and MMI with HITBW are similar when compared to COMT in PW at high risk of TDM2.Trial registration: The patients were part of a 12-week training study (ClinicalTrials.gov Identifier: NCT03200639).HIGHLIGHTSWe compared the effects a HIBWT with a COMT in PW at high risk of TDM2.Both training protocols increased MMI and 6MWT.Both training protocols improved HbA1c, insulin, HOMA-IR and glucose.Both training protocols increased IL1ra.The HIBWT is an alternative time-efficient treatment strategy for preventing TDM2.