DNA microarray for the identification of pathogens causing bloodstream infections

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Evaluation of: Tissari P, Zumla A, Tarkka E et al. Accurate and rapid identification of bacterial species from positive blood cultures with a DNA-based microarray platform: an observational study. Lancet 375(9710), 224–230 (2010).Rapid and accurate detection of life-threatening microbial pathogens with high morbidity and mortality is important for the treatment of suitable antibiotics to patients with infectious diseases. Recently, DNA microarray-based identification of pathogenic microorganisms has attracted much attention from clinical researchers owing to its efficiency, specificity and reproducible high-throughput capacities, compared with conventional culture-based diagnosis, which require a long period of time for cultivation and labor-intensive assay steps. In this article, we review recently published microarray-based diagnostic studies for accurate and rapid identification of pathogens infected in bloodstream and discuss the advantages and limitations over conventional diagnostic methods.

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