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To evaluate corneal biomechanical parameters wearing corneoscleral contact lenses (CScL) in patients with irregular corneas after laser in situ keratomileusis (LASIK).Data from patients fitted with CScL because of corneal surface irregularities after complicated LASIK surgery were selected by two eye clinics. Previously and after 1 year of CScL fitting, corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), and central corneal thickness were evaluated. In addition, visual acuity, subjective comfort, and wearing time CScL were reported.The study comprised 27 eyes. Statistically significant differences were found in visual acuity between the best spectacle-corrected vision and after CScL fitting [mean±SD, 0.16±0.03 logarithm of the minimum angle of resolution (logMAR) and 0.01±0.06 logMAR, respectively; P<0.001]. In addition, the patients reported high subjective comfort ratings (22 eyes were comfortable or very comfortable) and prolonged usage times (mean±SD, 12.67±1.98 hr of continuous wear a day). Statistically significant differences were found in the CRF between before CScL fitting and after 1 year of CScL wear (mean±SD, 7.57±0.87 and 7.68±0.84 mm Hg, respectively; P=0.015). Central corneal thickness, CH, and IOPcc showed slight differences after 1 year of CScL wear (1.78 μm, 0.04 and 0.21 mm Hg, respectively).Corneal biomechanical parameters increased slightly, although significantly for CRF, apparently without adverse clinical effects in post-LASIK eyes with irregular corneas after wearing CScL for 1 year.