Mechanistic explanations for counter-intuitive phosphorylation dynamics of the insulin receptor and insulin receptor substrate-1 in response to insulin in murine adipocytes

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Abstract

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The mathematical model described here has been submitted to the Online Cellular Systems Modelling Database and can be accessed at http://jjj.biochem.sun.ac.za/database/nyman/index.html free of charge.

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We report a counter-intuitive reversed order of peak values of protein phosphorylation in the early insulin signaling events in murine adipocytes. Using a conclusive modeling framework, we test different hypotheses and are able to draw non-trivial conclusions regarding possible mechanisms behind the reversed order of peaks. We also identify new differences between human and murine insulin signaling.

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