Metabolic reprogramming as a novel regulator of skeletal muscle development and regeneration

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Adult skeletal muscle contains a resident population of stem cells, termed satellite cells, that exist in a quiescent state. In response to an activating signal (such as physical trauma), satellite cells enter the cell cycle and undergo multiple rounds of proliferation, followed by differentiation, fusion, and maturation. Over the last 10–15 years, our understanding of the transcriptional regulation of this stem cell population has greatly expanded, but there remains a dearth of knowledge with regard to the initiating signal leading to these changes in transcription. The recent renewed interest in the metabolic regulation of both cancer and stem cells, combined with previous findings indicating that satellite cells preferentially colocalize with blood vessels, suggests that satellite cell function may be regulated by changes in cellular metabolism. This review aims to describe what is currently known about satellite cell metabolism during changes in cell fate, as well as to describe some of the exciting findings in other cell types and how these might relate to satellite cells.Adult skeletal muscle stem cells, termed satellite cells, are known to co-localize with blood vessels, indicating that satellite cell function may be linked to changes in the local metabolism. Here, the metabolic reprogramming of satellite cells during activation, specification, proliferation and differentiation is discussed, with reference to recent findings in other stem cell populations and tumor cells.

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