Programmed necrosis and necroptosis signalling

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Abstract

In recent years, the paradigm of cell death regulation has changed. Nowadays, not only apoptosis but also several forms of necrosis (e.g. necroptosis) are considered to be regulated. The central roles of receptor-interacting serine/threonine protein kinase1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like protein, and the molecular signalling platforms in which these molecules participate, are being intensively studied. In particular, the role of RIPK1, being both a kinase and a scaffold molecule, in different cell death regulatory complexes is of great relevance for the field. This minireview aims to introduce the emerging and dynamic field of necroptosis to the reader, with a specific focus on intracellular signalling pathways involved in this process.

The understanding of cell death has dramatically changed. Necrosis (e.g. RIPK-dependent necroptosis) is also executed in a genetically controlled manner. This minireview aims to introduce the process of necroptosis with a specific focus on intracellular signalling pathways. The central role of RIPK1/RIPK3/MLKL, the molecular signalling platforms where these molecules are activated, and recent in vivo evidence are described.

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