The cell's dilemma, or the story of cell death: an entertainment in three acts

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Abstract

Cells. They assemble, thrive, and cooperate to compose an organism, simple or complex. And like any living thing, they die. They die by catastrophe, they become sabotaged by condition, or they remove themselves on command from within or without. Each small life is followed by a death, to the benefit or the harm of the whole. Our story, here, is not of how each quietus occurs, but instead, of our ongoing effort to understand these tiny demises, to manipulate them, and to some day control them.

The Death Receptor Tango. The Mitochondrial Mambo. The Necroptosis Fandango. In this piece, Doug Green brings the molecular players regulating cell death to life. Cue music! Let's dance!

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