There is something about BOK we just don't get yet

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Abstract

Fernández-Marrero and colleagues show in their work that the proapoptotic BCL-2 family member BOK can form large, stable pores in artificial liposomes. This can be enhanced by the proapoptotic protein cBID and is unaffected by the antiapoptotic BCL-XL. Although BOK can bind to isolated mitochondria, it is unable to cause cytochrome c release even with the help of cBID.

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