Miller Fisher syndrome is a nodo-paranodopathy, but not a myelinopathy

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Abstract

Miller Fisher syndrome, characterized by ophthalmoplegia, ataxia and areflexia, is a variant of Guillain–Barré syndrome. There have been controversies over the electrophysiological studies of Miller Fisher syndrome, as both demyelinating and axonal changes have been reported. In recent years, reversible conduction failure has been reported in patients with Miller Fisher syndrome with the use of serial nerve conduction studies. The similarity between Miller Fisher syndrome and axonal Guillain–Barré syndrome has led to the suggestion of a common autoimmune mechanism at the nodes and paranodes.

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