Crosstalk between reactive oxygen species and nitric oxide in plants: Key role ofS-nitrosoglutathione reductase


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Abstract

Nitric oxide (.NO) acts as signaling molecule in plants being involved in diverse physiological processes such as germination, root growth, stomata closing and response to biotic and abiotic stress. S-Nitrosoglutathione (GSNO) is the storage and transport form of.NO and has a very important function in.NO signaling since it can transfer its.NO moiety to other proteins (trans-nitrosylation). The level of GSNO and thus the level of S-nitrosylated proteins are regulated by GSNO-reductase (GSNOR). In this way, this enzyme regulates the S-nitrosothiol levels and plays a balancing role in fine-tuning.NO signaling. Interestingly, oxidative post-translationally modification of GSNOR inhibited the activity of this enzyme suggesting a direct crosstalk between ROS- and RNS-signaling. In this review article the regulatory effects of ROS on GSNOR are highlighted and their physiological function in context of crosstalk between ROS and.NO and species in plants are discussed.Graphical abstractHighlightsHydrogen peroxide and nitric oxide modifies S-nitrosoglutathione reductase.Redox-modification of S-nitrosoglutathione reductase inhibits its activity.Accumulation of S-nitrosoglutathione initiates nitric oxide signaling.Accumulation of S-nitrosoglutathione initiates cellular antioxidative machinery.

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