Development of landslides in the Three Gorges Reservoir area is related to many factors. Lithology is one of the indispensable internal factors, besides relative height differences, slope gradients and slope profiles. We used an information value model with geographical information system (GIS) technology to study how lithology contributes to the development of landslides from the Yunyang to Wushan segment in the Three Gorges Reservoir area and we quantify the relationship between lithology and development of landslides. Via an investigation of 205 examples of past landslides, we found that the lithology of J3s, J3p and T2b contributes most. Our research results can provide a valid basis for future construction in the Three Gorges Reservoir area.