Effects of low concentrations copper on antioxidant responses, DNA damage and genotoxicity in thick shell musselMytilus coruscus


    loading  Checking for direct PDF access through Ovid

Abstract

For the aim to study potential detrimental effects induced by Cu exposure at low, environmentally relevant concentrations, the in vivo activities at different levels of biological organisations of thick shell mussel Mytilus coruscus exposed to two levels of copper were assessed. Cu-induced stresses were evaluated through antioxidant responses, DNA damage and genotoxicity. The results revealed significant higher SOD and CAT activities, and MDA concentration in haemocytes of M. coruscus with Cu exposure at 8 μg/L, while only significant accumulation in CAT activity with Cu exposure at 2 μg/L and no significant changes with SOD activity and MDA concentration at this level of Cu exposure. Copper exposure induced DNA damage as induction of OTM value in a time- and concentration-dependent manner. In addition, copper exposure could significantly induced the expressions of MT-10, Hsp70, Hsp90 and C3. The present results deepen the mussels as a suitable model marine invertebrate species to study potential detrimental effects induced by possible toxicants, in combinations at different levels of biological organisations.HighlightsChronic Cu exposure firstly performed in haemocytes of M. couruscus.Effects of copper on antioxidant responses, DNA damage and genotoxicity were assessed.Cu-induced oxidative stress might cause DNA damage and genotoxicity.

    loading  Loading Related Articles