APC I1307K and the E1317Q variants are not present in Chinese colorectal cancer patients

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Abstract

Purpose:

The APC I1307K and E1317Q variants predispose to colorectal adenomas and carcinomas in Caucasians, but data are lacking in Asians.

Methods and Results:

We sequenced the APC gene from codons 1261 to 1409 and found none of 147 Chinese, 20 Malay, and 11 Indian colorectal cancer patients in Singapore to carry the APC I1307K or E1317Q variants.

Conclusion:

These variants are rare in these Asian populations, and play little role in colorectal cancer causation in Chinese.

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