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To evaluate correlation between peripapillary retinal nerve fiber layer thickness (RNFL) and optic nerve head (ONH) parameters in normal participants using Spectral domain optical coherence tomography (OCT).Sixty-five eyes of 65 healthy participants aged 13–79 years underwent ONH analysis and peripapillary RNFL thickness measurements using spectral domain OCT. The RNFL measurements were correlated with the data obtained with ONH analysis.The average and quadrant RNFL thickness did not show correlation with optic disc area. A positive correlation was found between average RNFL thickness and rim area (r=0.425, P=0.000) and negative correlation between average RNFL thickness and cup area (r=−0.249, P<0.046).In our study, peripapillary RNFL thickness as measured by OCT did not show correlation with optic disc size. Despite a shorter distance between optic disc and circular scan margin, larger discs did not show a thicker RNFL. Interindividual variability of disc area probably minimizes the effect of various ONH size on RNFL thickness measurement.