Plasma Homocysteine Levels in Patients With Normal Tension Glaucoma


    loading  Checking for direct PDF access through Ovid

Abstract

PurposeTo investigate whether there is an association of elevated plasma levels of homocysteine (Hcy) and normal tension glaucoma (NTG).Patients and MethodsPlasma levels of Hcy (fluorescence polarization immunoassay), vitamin B6 (high-performance liquid chromatography), vitamin B12, and folate levels (immunoassay) were determined in 42 patients with NTG and in 42 age-matched and sex-matched controls.ResultsNo significant difference regarding Hcy (NTG: 10.95 μmol/L±2.65; controls: 11.29 μmol/L±2.76) (P=0.639), vitamin B6 (NTG: 14.45 ng/mL±12.89; controls: 13.57 ng/mL±10.41) (P=0.629), vitamin B12 (NTG: 387.73 pg/mL±282.04; controls: 423.27 pg/mL±188.85) (P=0.052) and folate (NTG: 9.45ng/mL±3.42; controls: 10.82 ng/mL±4.48) (P=0.181) levels were found between both groups.ConclusionsAn association of elevated Hcy levels and NTG was not found and therefore a role of Hcy as a modifiable risk factor in the pathogenesis of NTG seems unlikely.

    loading  Loading Related Articles